Mitochondrial dysfunction is associated with various chronic diseases and cancers, including neurodegenerative diseases and ...

Researchers from Karolinska Institutet have discovered how mammalian cells prevent the gradual buildup of harmful mutations in mitochondrial DNA, the small but vital genome that powers every cell. The ...

Longevity science has spent decades chasing single molecules that might slow aging, but most candidates have delivered modest ...

Scientists led by a team at the Medical Research Council (MRC) Mitochondrial Biology Unit, University of Cambridge, have worked out how a molecular machine found in mitochondria—the “powerhouses” of ...

Researchers have developed experimental compounds that make cells burn more calories by subtly tweaking how mitochondria ...

Hepatic cell carcinoma (HCC), the fifth most prevalent malignancy worldwide and the fourth leading cause of cancer-related mortality, poses significant therapeutic challenges. Despite advancements in ...

Researchers at the Department of Cell and Molecular Biology, Karolinska Institutet have captured the first detailed molecular snapshots of human polynucleotide phosphorylase (hPNPase) in action, ...

Scientists may have found a safer way to make cells burn more calories—by turning up the heat inside our cellular power plants.

Scientists have developed experimental compounds that prompt the mitochondria inside cells to use more energy and burn additional calories. This early ...