Picture in your mind a traditional “landline” telephone with a coiled cord connecting the handset to the phone. The coiled telephone cord and the DNA double helix that stores the genetic material in ...

A cell has many ways to regulate gene expression, one of which is the structure of the genome itself; active genes have to be accessible to the cellular machinery to be expressed. The DNA in the ...

When people think of DNA, they visualize a string-like double helix structure. In reality, the DNA double helix in cells is supercoiled and constrained into loops. This supercoiling and looping are ...

Even living cells have their own tangled problems to solve. They involve knots that arise accidentally in DNA and that can comprise its functionality. A new study by SISSA (Scuola Internazionale ...

Researchers from Durham University, Jagiellonian University (Poland) and the John Innes Centre have achieved a breakthrough in understanding DNA gyrase, a vital bacterial enzyme and key antibiotic ...

A team of physicists working at the intersection of theory and experiment are shedding new light on the 'teamwork' of molecular motors -- called RNA polymerases (RNAPs) -- that mediate DNA ...

The double helix of DNA is one of the most iconic symbols in science. By imitating the structure of this complex genetic molecule we have found a way to make artificial muscle fibers far more powerful ...

Tiny robots could serve all kinds of useful functions, but shrinking their actuators has proven challenging. Now researchers at the University of Wollongong (UOW) in Australia have made artificial ...

This is a preview. Log in through your library . Abstract The activation-induced cytidine deaminase (AID) is required for somatic hypermutation (SHM) and class-switch recombination of Ig genes. It has ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 86, No. 16 (Aug. 15, 1989), pp. 6121-6125 (5 pages) Incubation of topologically relaxed plasmid DNA with simian ...

Supercoil me! The art of knotted DNA maintenance Supercoiling can keep DNA knots locked in place for long enough that they can be untied by specialised enzymes, a new study says Date: July 5, 2018 ...