aProximate TM is an advanced in vitro model of kidney proximal tubule cells (PTCs) that closely mimics physiological conditions. Derived from fresh human kidney tissue, aProximate TM PTCs are cultured ...

Vol. 57, No. 2, SPECIAL REVIEW SERIES ON 3D ORGANOTYPIC AND ORGANOID CULTURE MODELS (FEBRUARY 2021), pp. 133-147 (15 pages) The human kidney, which consists of up to 2 million nephrons, is critical ...

Researchers developed tubuloids from adult kidney cells. When exposed to cisplatin, the model replicated key steps in the chronic kidney disease progression, including DNA damage, cellular senescence, ...

A robust model, such as aProximate TM, is required to study renal dysfunction and perform in vitro kidney disease modeling. This model expresses all transporters specialized in drug, solute, and ...

For the first time, researchers from both Sheba Medical Center and Tel Aviv University have grown human kidney organoids (a synthetic 3D organ culture) from tissue stem cells in the laboratory, ...

KAIST researchers developed a modular organ-on-a-chip that reproduces rhabdomyolysis, revealing how drug-induced muscle ...

“You’re on a chemotherapeutic and your oncologist may say that your dosage is X, while a nephrologist is telling you that the proximal tubules in your kidneys can’t handle it. You’re harming them.” ...

Chronic kidney disease (CKD) is a progressive condition that begins with tissue damage and gradually leads to loss of kidney function. The condition, which affects about 10% of the global population, ...