The laboratory mouse has become the premier model organism for mammalian genetics. Initially, the ability to generate inbred strains fueled this popularity, and many such strains were developed. The ...

After 5-10 generations of inbreeding, mouse colonies should be “refreshed”, to remove or prevent genetic drift accumulation in the colony. Several methods to refresh the genetic background may include ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 77, No. 10, [Part 2: Biological Sciences] (Oct., 1980), pp. 5779-5783 (5 pages) A specific probe for detecting ...

Researchers have created genome-wide, high-resolution genetic maps of 100 inbred mouse strains. Compared with wild-derived strains, most of today's classical lab strains have limited genetic diversity ...

Technologies at the Advanced Rodent Transgenics Laboratory include genome editing design and implementation and transgenic ...

B. Yalcin, J. Fullerton, S. Miller, D. A. Keays, S. Brady, A. Bhomra, A. Jefferson, E. Volpi, R. R. Copley, J. Flint, R. Mott, David E. Housman Proceedings of the ...

To the average life-science researcher, a mouse’s genetic background may be an afterthought, if even a thought, at all. A researcher’s top priorities may be to understand disease, to publish, and to ...

A recent study from the University of Eastern Finland shows that genetic variation determines chromatin accessibility and the binding of transcription factors. Chromatin consists of DNA and proteins ...

The great majority of how we understand human disease, and attempt to cure it, derives from mice genetically fashioned to be prolific breeders, docile and easy to handle – all qualities that have made ...

The Institute for Behavioral Genetics has the world's most complete collection of mouse strains that have been engineered to express mutations in nicotinic cholinergic receptor (nAChR) subunit genes.

A team of scientists in France recently developed a mouse-adapted strain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that efficiently replicates in the lungs of standard laboratory ...