Abstract HighlightsORIC-944 is a potent, highly selective, orally bioavailable, allosteric inhibitor of PRC2 that demonstrates best-in-class drug properties, including potency, solubility, and ...
Changes in histone modifications of genes involved in flowering. (a) The removal of Polycomb complexes by SDG7 protein. (b) Transcription elongation and the deposition of H3K36me3 by SDG8 protein. PRE ...
Scientists have discovered how mutations in a specific gene drive the rare developmental disorder Weaver syndrome, which is marked by intellectual disability and overgrowth and predisposes people with ...
Dysregulation of the polycomb repressive complex 2 (PRC2) is associated with epigenetic silencing of tumor suppressor genes, leading to alterations in cell proliferation, differentiation and survival ...
Polycomb repressive complex 2 (PRC2) can both read and write H3K27me3, enabling progressive spreading of H3K27me3 on the linear genome. Long-range Polycomb-associated DNA contacts have also been ...
Scientists have discovered how mutations in a specific gene drive the rare developmental disorder Weaver syndrome, which is marked by intellectual disability and overgrowth and predisposes people with ...
One of the most fascinating discoveries in biology is that cells have mechanisms for dynamically regulating genetic expression. This ability to promote or restrict the transcription of specific genes ...
Epigenetics, the dynamic regulation of genetic expression, involves complex molecular mechanisms. While the process of gene silencing by methylating the H3K27 position in histones is understood, not ...
Some results have been hidden because they may be inaccessible to you
Show inaccessible results
Feedback