A spliceosome is a large ribonucleoprotein (RNP) complex found primarily within the nucleus of eukaryotic cells. The spliceosome is assembled from small nuclear RNAs (snRNA) and numerous …

Nuclear pre-mRNA splicing is catalyzed by the spliceosome, a multi-megadalton ribonucleoprotein (RNP) complex. Both the conformation and composition of the spliceosome are highly dynamic, …

Mar 2, 2015 · Human cells contain two types of spliceosome: the major spliceosome responsible for removing 99.5% of introns and the minor spliceosome, which removes the remaining 0.5%.

Cryoelectron microscopy is being used to explore the many steps of spliceosome action. Spliceosomes are highly dynamic machines, however, so these structures only reveal the more stable portions of …

All these features make spliceosome a protein-dependent metalloribozyme which performs substrate-assisted catalysis. This places spliceosome in a different league from ribosome since in the latter …

Jul 1, 2011 · The extensive interplay of RNA and proteins in aligning the pre-mRNA's reactive groups, and the presence of both RNA and protein at the core of the splicing machinery, suggest that the …

Nuclear pre-mRNA splicing is catalyzed by the spliceosome, a multi-megadalton ribonucleoprotein (RNP) complex. Both the conformation and composition of the spliceosome are highly dynamic, …

Jan 23, 2014 · How do cells coordinate the assembly of this molecular machine? And how does the spliceosome accurately recognize exons and introns to carry out the splicing reaction?

Apr 19, 2022 · The spliceosome is a highly dynamic and heterogeneous metal ribozyme; During the splicing reaction, the dynamic spliceosome has an immobile core of about 20 protein and RNA …

The spliceosome is a dynamic complex whose components undergo multiple conformational and compositional changes during the splicing reaction. Such rearrangements occur between snRNAs, …